Addressing the Critical Nexus of Aging and Disease
As we age, several things happen:
- Our cells express fewer of the Estrogen Related Receptors (ERR) and Rev-Erb recetpors.
- Diseases of aging start to occur. In many of these diseases, the key pathways regulated by REV-ERB and ERR become dysregulated.
- Because of injury and disease, aging individuals can become can become intolerant and can no longer benefit from actual exercise.
Pelagos’s exercise mimetics are being designed to prevent and treat age-related disease to enhance health span and longevity.
It has been demonstrated in animal models that targeting these receptors can treat multiple diseases (heart failure, muscle-wasting diseases, cognitive decline).